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Epidemic obesity in children and adolescents: risk factors and prevention
Eun Young Lee, Kun-Ho Yoon
《医学前沿(英文)》 2018年 第12卷 第6期 页码 658-666 doi: 10.1007/s11684-018-0640-1
关键词: obesity children adolescents epidemiology risk factor prevention
G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma
Wenjing Wang, Shigang Ding, Hejun Zhang, Jun Li, Jun Zhan, Hongquan Zhang
《医学前沿(英文)》 2019年 第13卷 第4期 页码 482-491 doi: 10.1007/s11684-018-0633-0
关键词: LGR6 colon adenocarcinoma immunohistochemistry prognosis
Clinical and genetic risk factors for venous thromboembolism in Chinese population
Chen WANG PhD, MD, Zhen-Guo ZHAI PhD, MD, Ying H. SHEN PhD, MD, Lan ZHAO PhD, MD,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 29-35 doi: 10.1007/s11684-010-0012-y
关键词: risk factor stroke prothrombin plasminogen activator inhibitor type-1 polymorphism thrombophilia biomarker
Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease
Min Fei, Li Xiang, Xichen Chai, Jingchun Jin, Tao You, Yiming Zhao, Changgeng Ruan, Yiwen Hao, Li Zhu
《医学前沿(英文)》 2020年 第14卷 第1期 页码 81-90 doi: 10.1007/s11684-019-0692-x
关键词: soluble C-type lectin-like receptor-2 coronary artery disease risk factor
Salman HABIB, Muhammad Mansoor KHAN, Farukh ABBAS, Muhammad NUMAN, Yaqoob ALI, Houjun TANG, Xuhui YAN
《能源前沿(英文)》 2020年 第14卷 第2期 页码 298-317 doi: 10.1007/s11708-019-0648-5
关键词: electric vehicles (EVs) residential distribution networks (RDNs) voltage unbalance factor (VUF) state-of charge (SOC) time-of-use (TOU)
《医学前沿(英文)》 2023年 第17卷 第3期 页码 518-526 doi: 10.1007/s11684-022-0958-6
关键词: acute lymphoblastic leukemia child venous thromboembolism epidemiology clinical characteristic risk factor
Clinical characteristics and risk factors for mortality in cancer patients with COVID-19
Junnan Liang, Guannan Jin, Tongtong Liu, Jingyuan Wen, Ganxun Li, Lin Chen, Wei Wang, Yuwei Wang, Wei Liao, Jia Song, Zeyang Ding, Xiao-ping Chen, Bixiang Zhang
《医学前沿(英文)》 2021年 第15卷 第2期 页码 264-274 doi: 10.1007/s11684-021-0845-6
Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance
null
《医学前沿(英文)》 2012年 第6卷 第4期 页码 376-380 doi: 10.1007/s11684-012-0228-0
The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediating chemotherapy sensitivity and resistance. Recent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional target repressed by the forkhead protein FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling pathway. Intriguingly, FOXM1 and FOXO3a also compete for binding to the same gene targets, which have a role in chemotherapeutic drug action and sensitivity. An understanding of the role and regulation of the FOXO-FOXM1 axis will impact directly on our knowledge of chemotherapeutic drug action and resistance in patients, and provide new insights into the design of novel therapeutic strategy and reliable biomarkers for prediction of drug sensitivity.
关键词: FOXO3a FOXM1 transcription factor cancer drug resistance tumorigenesis
Understanding and addressing the environmental risk of microplastics
《环境科学与工程前沿(英文)》 2023年 第17卷 第1期 doi: 10.1007/s11783-023-1612-5
Over the past decades, the plastic production has been dramatically increased. Indeed, a category of small plastic particles mainly with the shapes of fragments, fibers, or spheres, called microplastics (particles smaller than 5 mm) and nanoplastics (particles smaller than 1 μm) have attracted particular attention. Because of its wide distribution in the environment and potential adverse effects to animal and human, microplastic pollution has been reported as a serious environment problem receiving increased attention in recent years. As one of the commonly detected emerging contaminants in the environment, recent evidence indicates that the concentration of microplastics show an increasing trend, for the reason that up to 12.7 million metric tons of plastic litter is released into aquatic environment from land-based sources each year. Furthermore, microplastic exposure levels of model organisms in laboratory studies are usually several orders of magnitude higher than those found in environment, and the microplastics exposure conditions are also different with those observed in the environment. Additionally, the detection of microplastics in feces indicates that they can be excreted out of the bodies of animal and human. Hence, great uncertainties might exist in microplastics exposure and health risk assessment based on current studies, which might be exaggerated. Policies reduce microplastic emission sources and hence minimize their environmental risks are determined. To promote the above policies, we must first overcome the technical obstacles of detecting microplastics in various samples.
关键词: Emerging contaminants Microplastics Environment risk Health effect
LSSVM-based approach for refining soil failure criteria and calculating safety factor of slopes
Shiguo XIAO; Shaohong LI
《结构与土木工程前沿(英文)》 2022年 第16卷 第7期 页码 871-881 doi: 10.1007/s11709-022-0863-8
关键词: slope stability safety factor failure criterion least square support vector machine
lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis
《医学前沿(英文)》 2023年 第17卷 第2期 页码 317-329 doi: 10.1007/s11684-022-0931-4
关键词: lncR-GAS5 miR-193-5p splicing factor SRSF10 autophagy atherogenesis
The calculation of equivalence factor for ecological footprints in China: a methodological note
Moucheng LIU,Wenhua LI,Dan ZAHNG,Ning SU
《环境科学与工程前沿(英文)》 2015年 第9卷 第6期 页码 1015-1024 doi: 10.1007/s11783-014-0670-0
关键词: ecological footprint equivalence factor net primary production biological capacity land types
Ecological Risk Management of Drinking Water Project: The Case Study of Kunming City
Ji-liang Zheng,Jun Hu,Xuan Zhou,Ching Yuen Luk
《工程管理前沿(英文)》 2015年 第2卷 第3期 页码 311-319 doi: 10.15302/J-FEM-2015045
关键词: drinking water project ecological risk ecological risk assessment risk management
《结构与土木工程前沿(英文)》 2021年 第15卷 第4期 页码 877-894 doi: 10.1007/s11709-021-0756-2
关键词: bridges multi-lane factor traffic load lane load disparity multi-truck presence weigh-in-motion data
朱启超,匡兴华,沈永平
《中国工程科学》 2003年 第5卷 第1期 页码 89-94
技术项目的风险管理一直深受美国国防部的重视。介绍了在美国国防采办风险管理中广泛应用的风险矩阵方法,并对其优缺点和适用性进行分析,结合我国国防预研技术项目管理的特点,提出我国开展技术性项目风险管理的思路。
标题 作者 时间 类型 操作
Epidemic obesity in children and adolescents: risk factors and prevention
Eun Young Lee, Kun-Ho Yoon
期刊论文
G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma
Wenjing Wang, Shigang Ding, Hejun Zhang, Jun Li, Jun Zhan, Hongquan Zhang
期刊论文
Clinical and genetic risk factors for venous thromboembolism in Chinese population
Chen WANG PhD, MD, Zhen-Guo ZHAI PhD, MD, Ying H. SHEN PhD, MD, Lan ZHAO PhD, MD,
期刊论文
Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease
Min Fei, Li Xiang, Xichen Chai, Jingchun Jin, Tao You, Yiming Zhao, Changgeng Ruan, Yiwen Hao, Li Zhu
期刊论文
A framework for stochastic estimation of electric vehicle charging behavior for risk assessment of distribution
Salman HABIB, Muhammad Mansoor KHAN, Farukh ABBAS, Muhammad NUMAN, Yaqoob ALI, Houjun TANG, Xuhui YAN
期刊论文
Venous thromboembolism in children with acute lymphoblastic leukemia in China: a report from the Chinese Children’s Cancer Group-ALL-2015
期刊论文
Clinical characteristics and risk factors for mortality in cancer patients with COVID-19
Junnan Liang, Guannan Jin, Tongtong Liu, Jingyuan Wen, Ganxun Li, Lin Chen, Wei Wang, Yuwei Wang, Wei Liao, Jia Song, Zeyang Ding, Xiao-ping Chen, Bixiang Zhang
期刊论文
LSSVM-based approach for refining soil failure criteria and calculating safety factor of slopes
Shiguo XIAO; Shaohong LI
期刊论文
lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis
期刊论文
The calculation of equivalence factor for ecological footprints in China: a methodological note
Moucheng LIU,Wenhua LI,Dan ZAHNG,Ning SU
期刊论文
Ecological Risk Management of Drinking Water Project: The Case Study of Kunming City
Ji-liang Zheng,Jun Hu,Xuan Zhou,Ching Yuen Luk
期刊论文
A practical multi-lane factor model of bridges based on multi-truck presence considering lane load disparities
期刊论文